猪源天然5-羟色胺3受体不包含烟碱型乙酰胆碱受体亚基的证据。
Evidence that porcine native 5-HT3 receptors do not contain nicotinic acetylcholine receptor subunits.
作者信息
Fletcher S, Lindstrom J M, McKernan R M, Barnes N M
机构信息
Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, UK.
出版信息
Neuropharmacology. 1998;37(3):397-9. doi: 10.1016/s0028-3908(98)00052-5.
PMID:9681938
Abstract
The present investigation utilised monoclonal antibodies directed against subunits of the nicotinic acetylcholine receptor in immunoblot and immunoprecipitation studies, which failed to demonstrate that the native 5-hydroxytryptamine3 (5-HT3) receptor complex purified from porcine brain contains the alpha1, alpha3, alpha4, alpha5, alpha7 or beta2 subunits of the nicotinic acetylcholine receptor.
摘要
本研究在免疫印迹和免疫沉淀研究中使用了针对烟碱型乙酰胆碱受体亚基的单克隆抗体，结果未能证明从猪脑中纯化的天然5-羟色胺3（5-HT3）受体复合物含有烟碱型乙酰胆碱受体的α1、α3、α4、α5、α7或β2亚基。
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