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Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats.

作者信息

Carasso B S, Bakshi V P, Geyer M A

机构信息

Department of Neurosciences, University of California at San Diego, La Jolla 92093-0804, USA.

出版信息

Neuropharmacology. 1998;37(3):401-4. doi: 10.1016/s0028-3908(98)00051-3.

DOI:10.1016/s0028-3908(98)00051-3
PMID:9681939
Abstract

The role of the alpha-1 adrenoceptor in prepulse inhibition (PPI) was evaluated in rats. The alpha-1 adrenergic agonist cirazoline disrupted PPI; this effect was reversed by the alpha-1 adrenergic antagonist prazosin or the atypical antipsychotic quetiapine. Alpha-1 adrenoceptors may thus be involved in the regulation of PPI and in the psychotherapeutic actions of certain antipsychotics.

摘要

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