Papaioannou N, Vlemmas I, Balaskas N, Tsangaris T
Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece.
Vet Hum Toxicol. 1998 Aug;40(4):203-7.
The ultra-structural lesions of lead poisoning and the deposition of lead in liver, kidney, peritoneum, cerebellum and retina of dogs were studied. Specimens were obtained from 5 3-4 mo-old crossbreed dogs each injected i.p. with a total dose of 120 mg lead acetate, divided in 10 equal doses of 12 mg, administered every other day. Two dogs were controls. Histopathological examination revealed degeneration of the epithelial cells of the urinary tubules, the endothelial cells of the renal capillaries and the hepatocytes. Characteristic lead inclusion bodies were observed intracytoplasmically and intranuclearly in mesothelial and giant cells of the peritoneum. Lead needle-like inclusions were intracytoplasmically in the interstitial connective tissue cells of the kidney, and substantial quantities of lead were in collagen fibers of the interstitial kidney tissue.
研究了铅中毒的超微结构病变以及铅在犬肝脏、肾脏、腹膜、小脑和视网膜中的沉积情况。从5只3 - 4月龄的杂种犬获取标本，每只犬经腹腔注射120 mg醋酸铅，分10等份，每份12 mg，每隔一天注射一次。2只犬作为对照。组织病理学检查显示肾小管上皮细胞、肾毛细血管内皮细胞和肝细胞发生变性。在腹膜间皮细胞和巨细胞的细胞质和细胞核内观察到特征性的铅包涵体。在肾脏间质结缔组织细胞的细胞质内有铅针状包涵体，且肾脏间质组织的胶原纤维中有大量铅。
