Buckalew V M, Gonick H C
Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1053, USA.
Clin Exp Hypertens. 1998 Jul-Aug;20(5-6):481-8. doi: 10.3109/10641969809053226.
An international symposium on natriuretic and digitalis-like factors was convened for the first time since 1992. Topics discussed included structures and biosynthesis of endogenous digitalis-like factors (EDLF), biologic activities, physiology function and role of EDLF in hypertension, and novel natriuretic factors. Progress was reported in determining the exact structure of an isomer of ouabain isolated from bovine hypothalamus. Evidence was presented supporting the existence of a second mammalian EDLF that resembles steroids found in toads (bufodienolides). Support for endogenous synthesis of mammalian EDLF was also presented. Mammalian EDLF were reported to have effects which are different from those possessed by digitalis like steroids derived from plants. New evidence was presented implicating EDLF in various forms of hypertension in humans and animal models. Finally, several unique natriuretic factors that do not inhibit Na, K ATPase and that appear to play a role in mammalian volume regulation were discussed.
自1992年以来，首次召开了关于利钠因子和类洋地黄因子的国际研讨会。讨论的主题包括内源性类洋地黄因子（EDLF）的结构与生物合成、生物活性、生理功能以及EDLF在高血压中的作用，还有新型利钠因子。报告了在确定从牛下丘脑分离出的哇巴因异构体的确切结构方面取得的进展。有证据表明存在第二种类似于蟾蜍中发现的类固醇（蟾毒配基）的哺乳动物EDLF。也有证据支持哺乳动物EDLF的内源性合成。据报道，哺乳动物EDLF具有的作用不同于源自植物的类洋地黄类固醇所具有的作用。有新证据表明EDLF与人类和动物模型中各种形式的高血压有关。最后，讨论了几种不抑制钠钾ATP酶且似乎在哺乳动物容量调节中起作用的独特利钠因子。
