Abe S, Suzuki T, Hori T, Baba A, Shiraishi H
Department of Psychiatry, Institute of Clinical Medicine, The University of Tsukuba, Japan.
Psychiatry Clin Neurosci. 1998 Feb;52(1):115-7. doi: 10.1111/j.1440-1819.1998.tb00983.x.
Hypogammaglobulinemia in a 22-year-old woman with brief psychotic disorder developed during antipsychotic therapy. Severe decreases in immunoglobulin IgM, IgG, and IgA concentration in serum were observed 4 months after the treatment with chlorpromazine (CPZ) and the other types of antipsychotics. Neither physical diseases nor family history for immunological disturbances was seen. No clinical symptoms in relation to immunological disturbances (i.e. infectious disease), were noted. Gammaglobulin levels in serum returned to a normal range after a replacement of chlorpromazine to timiperone. The hypogammaglobulinemia in the present case was considered to be due to the inhibition of gammaglobulin synthesis by CPZ.
一名患有短暂性精神病性障碍的22岁女性在抗精神病药物治疗期间出现低丙种球蛋白血症。在用氯丙嗪（CPZ）和其他类型抗精神病药物治疗4个月后，观察到血清中免疫球蛋白IgM、IgG和IgA浓度严重下降。未发现躯体疾病或免疫紊乱家族史。未观察到与免疫紊乱相关的临床症状（即传染病）。将氯丙嗪换成替米哌隆后，血清中γ球蛋白水平恢复到正常范围。本病例中的低丙种球蛋白血症被认为是由于CPZ抑制γ球蛋白合成所致。
