Garcia Rodriguez M C, de la Concha E G, Fontán G, Pascual-Salcedo D, Fernandez J, Ojeda J A, Garcia Diaz A
J Clin Lab Immunol. 1983 May;11(1):55-8.
The woman described suffered from a pruritic erythematous rash, edema, malaise and fever which appeared during Tegretol therapy. The patient was shown to have a severe hypogammaglobulinemia with absence of circulating B lymphocytes, but normal cell-mediated immunity. There was an absence of in vitro immunoglobulin production by the patient's cells, but this was not due to excessive T-suppressor activity or lack of T-cell help. When drug administration was stopped the edema and rash began to recede promptly, and a few months later her serum immunoglobulin levels, antibody titers and in vitro immunoglobulin production became normal. This transient, probably drug-dependent case of hypogammaglobulinemia, added to three previously reported cases, stresses the need of considering non-conventional immunosuppressive drugs as a potential-etiological agent in acquired hypogammaglobulinemia.
该名女性患者在服用卡马西平治疗期间出现瘙痒性红斑皮疹、水肿、不适和发热症状。检查发现该患者存在严重的低丙种球蛋白血症，循环B淋巴细胞缺失，但细胞介导免疫功能正常。患者细胞在体外不能产生免疫球蛋白，但这并非由于T抑制细胞活性过高或缺乏T细胞辅助所致。停药后，水肿和皮疹迅速消退，几个月后其血清免疫球蛋白水平、抗体滴度及体外免疫球蛋白产生均恢复正常。这例短暂的、可能与药物相关的低丙种球蛋白血症病例，加上之前报道的3例病例，强调了在获得性低丙种球蛋白血症中需要考虑将非常规免疫抑制药物作为潜在病因的必要性。
