Schultheiss P C, Collins J K, Austgen L E, DeMartini J C
Department of Pathology, Colorado State University, Fort Collins 80523, USA.
J Vet Diagn Invest. 1998 Jul;10(3):255-62. doi: 10.1177/104063879801000305.
Acute malignant catarrhal fever (MCF) was diagnosed in 10 bison from 6 herds and ranging from 1 to 6 years of age. The pattern of clinical signs and morphologic lesions differed among bison. Combinations of corneal opacity, lacrimation, nasal discharge, depression, excess salivation, anorexia, diarrhea, melena, and hematuria were observed. Vasculitis characterized by lymphoid infiltrates in the adventia with variable extension into media and intima was found in multiple tissues in each animal. Fibrinoid vascular necrosis was rare. Ulceration in the alimentary tract was found in 9/10 bison, and ulceration or hemorrhage in the urinary bladder was found in 8/10 bison. Lymphoid infiltrates were present in 7 of 9 livers and 9 of 9 kidneys examined histologically. Hyperplasia of lymph nodes was observed in 5 bison. Chronic MCF was diagnosed in 1 bison with an 80-day course of illness that began with lacrimation, corneal opacity, mucoid nasal discharge, depression, and anorexia. These signs ceased after 15 days but circling and blindness developed on day 76. Chronic vascular lesions characterized by endothelial cell hypertrophy, intimal thickening, fragmentation of the internal elastic membrane, smooth muscle hypertrophy, and adventitial infiltrates of lymphocytes and plasma cells were found in many organs. The retinal arteries had chronic inflammation and acute transmural fibrinoid necrosis. The retinas were infarcted. Polymerase chain reaction technique for amplification of ovine herpesvirus 2 sequences was performed on formalin-fixed tissues, and viral sequences were detected in 1-7 tissues from each animal. These viral sequences were not found in tissues of 4 bison not affected by MCF.
在来自6个牛群、年龄从1岁到6岁的10头野牛中诊断出急性恶性卡他热（MCF）。野牛的临床症状和形态学病变模式各不相同。观察到角膜混浊、流泪、鼻液、抑郁、流涎过多、厌食、腹泻、黑便和血尿等症状组合。在每只动物的多个组织中发现了以血管外膜淋巴细胞浸润为特征的血管炎，浸润程度不一，可延伸至中膜和内膜。纤维蛋白样血管坏死很少见。10头野牛中有9头在消化道发现溃疡，10头野牛中有8头在膀胱发现溃疡或出血。在组织学检查的9个肝脏中有7个和9个肾脏中有9个存在淋巴细胞浸润。5头野牛观察到淋巴结增生。1头野牛被诊断为慢性MCF，病程80天，始于流泪、角膜混浊、黏液性鼻液、抑郁和厌食。这些症状在15天后消失，但在第76天出现转圈和失明。在许多器官中发现了以内皮细胞肥大、内膜增厚、内弹性膜破碎、平滑肌肥大以及淋巴细胞和浆细胞的血管外膜浸润为特征的慢性血管病变。视网膜动脉有慢性炎症和急性透壁纤维蛋白样坏死。视网膜发生梗死。对福尔马林固定的组织进行了用于扩增绵羊疱疹病毒2序列的聚合酶链反应技术，在每只动物的1 - 7个组织中检测到病毒序列。在4头未受MCF影响的野牛组织中未发现这些病毒序列。
