Fechtner R D, Khouri A S, Zimmerman T J, Bullock J, Feldman R, Kulkarni P, Michael A J, Realini T, Warwar R
Department of Ophthalmology, University of Medicine and Dentistry of New Jersey, Newark 07103, USA.
Am J Ophthalmol. 1998 Jul;126(1):37-41. doi: 10.1016/s0002-9394(98)00071-3.
To report the association of anterior uveitis with the use of latanoprost.
We studied four patients with complicated open-angle glaucoma who had anterior uveitis associated with the use of latanoprost. The uveitis was unilateral and occurred only in the eye receiving latanoprost in three patients. In one patient, latanoprost was used in both eyes, and the uveitis was bilateral. Four of five eyes had a history of prior inflammation and/or prior incisional surgery. All patients were rechallenged with the drug.
The uveitis improved after cessation of latanoprost with or without topical corticosteroids. It recurred after rechallenging with latanoprost in all eyes.
There is a possible association between latanoprost and anterior uveitis. Topical prostaglandin analogs may be relatively contraindicated in patients with a history of uveitis or prior ocular surgery. This association may also be possible in eyes that have not had previous uveitis or incisional surgery.
报告前葡萄膜炎与使用拉坦前列素之间的关联。
我们研究了4例患有复杂性开角型青光眼且前葡萄膜炎与使用拉坦前列素相关的患者。葡萄膜炎为单侧，3例患者仅发生在使用拉坦前列素的眼。1例患者双眼使用拉坦前列素，葡萄膜炎为双侧。5只眼中有4只眼有既往炎症和/或既往切开手术史。所有患者均再次使用该药物。
停用拉坦前列素后，无论是否使用局部皮质类固醇，葡萄膜炎均有改善。再次使用拉坦前列素后，所有眼的葡萄膜炎均复发。
拉坦前列素与前葡萄膜炎之间可能存在关联。有葡萄膜炎病史或既往眼部手术史的患者可能相对禁忌使用局部前列腺素类似物。在既往无葡萄膜炎或切开手术史的眼中也可能存在这种关联。
