den Broeder E, Lippens R J, van't Hof M A, Tolboom J J, van Staveren W A, Hofman Z, Sengers R C
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
Eur J Clin Nutr. 1998 Jul;52(7):494-500. doi: 10.1038/sj.ejcn.1600589.
To study the effect of sufficient energy intake, by means of the protocolized administration of naso-gastric tube feeding, on the nutritional status of a child with cancer.
A comparative experimental study.
Tertiary care at the Centre for Pediatric Oncology, South East Netherlands, University Hospital, Nijmegen.
Seven children, newly diagnosed with cancer, were included in the experimental study and all completed the trial period. Fourteen patients were included in the retrospective study. They were randomly chosen from a group of patients previously treated for a malignancy at our department and who had received naso-gastric tube feeding for at least 16 weeks.
Protocolized (experimental group) vs non-protocolized (retrospective group) administration of naso-gastric tube feeding over a period of 16 weeks. The main difference was the amount of tube feeding administered. In addition to energy from other foods, children in the experimental group received 106+/-13% of their total daily energy requirements (TDER) by means of tube feeding, whereas children in the retrospective group had received 75+/-24%.
Weight as a percentage of weight for height according to the 50th percentile of a healthy reference population=ideal weight.
Weight, expressed as a percentage of the ideal weight, increased significantly in the experimental group (18.2 8.4; P=0.01) and the retrospective study group (5.2 7.3; P=0.001). However, the increase was statistically significant in favour of the experimental group (P=0.003), in which all the children reached their ideal weight, compared to 21% in the retrospective group.
Aggressive protocolized nutritional intervention during the intensive phase of anti-cancer treatment, in the form of naso-gastric tube feeding that provides the child's total daily energy requirements, results in considerable improvement in the nutritional status.
通过规范的鼻胃管喂养方案，研究充足能量摄入对癌症患儿营养状况的影响。
一项对比实验研究。
荷兰东南部奈梅亨大学医院儿科肿瘤中心的三级护理机构。
7名新诊断为癌症的儿童被纳入实验研究，且均完成了试验期。14名患者被纳入回顾性研究。他们是从我们科室之前接受过恶性肿瘤治疗且接受鼻胃管喂养至少16周的一组患者中随机选取的。
在16周的时间内进行规范的（实验组）与非规范的（回顾性研究组）鼻胃管喂养。主要区别在于管饲的量。除了从其他食物中获取的能量外，实验组儿童通过管饲获得其每日总能量需求（TDER）的106±13%，而回顾性研究组儿童获得的是75±24%。
根据健康参考人群第50百分位数计算的体重占身高体重的百分比=理想体重。
以理想体重的百分比表示的体重，在实验组（18.2±8.4；P=0.01）和回顾性研究组（5.2±7.3；P=0.001）中均显著增加。然而，实验组的增加在统计学上更显著（P=0.003），实验组所有儿童都达到了理想体重，而回顾性研究组只有21%的儿童达到。
在抗癌治疗的强化阶段，以提供儿童每日总能量需求的鼻胃管喂养形式进行积极的规范营养干预，可使营养状况得到显著改善。
