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1
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2
Comparison of PhoP binding to the tuaA promoter with PhoP binding to other Pho-regulon promoters establishes a Bacillus subtilis Pho core binding site.将PhoP与tuaA启动子的结合同PhoP与其他Pho调控子启动子的结合进行比较，从而确定了枯草芽孢杆菌的Pho核心结合位点。
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3
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In Bacillus subtilis 168, teichoic acid of the cross-wall may be different from that of the cylinder: a hypothesis based on transcription analysis of tag genes.在枯草芽孢杆菌168中，横壁的磷壁酸可能与柱状部分的磷壁酸不同：基于tag基因转录分析的假说。
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本文引用的文献

1
PhoP-P and RNA polymerase sigmaA holoenzyme are sufficient for transcription of Pho regulon promoters in Bacillus subtilis: PhoP-P activator sites within the coding region stimulate transcription in vitro.PhoP-P与RNA聚合酶σA全酶足以启动枯草芽孢杆菌中Pho调控子启动子的转录：编码区内的PhoP-P激活位点在体外可刺激转录。
Mol Microbiol. 1998 Jun;28(6):1187-97. doi: 10.1046/j.1365-2958.1998.00882.x.
2
Comparison of PhoP binding to the tuaA promoter with PhoP binding to other Pho-regulon promoters establishes a Bacillus subtilis Pho core binding site.将PhoP与tuaA启动子的结合同PhoP与其他Pho调控子启动子的结合进行比较，从而确定了枯草芽孢杆菌的Pho核心结合位点。
Microbiology (Reading). 1998 May;144 ( Pt 5):1443-1450. doi: 10.1099/00221287-144-5-1443.
3
Sites internal to the coding regions of phoA and pstS bind PhoP and are required for full promoter activity.phoA和pstS编码区域内部的位点可结合PhoP，且是实现完整启动子活性所必需的。
Mol Microbiol. 1998 Apr;28(1):119-30. doi: 10.1046/j.1365-2958.1998.00779.x.
4
Analysis of Bacillus subtilis tagAB and tagDEF expression during phosphate starvation identifies a repressor role for PhoP-P.在磷酸盐饥饿期间对枯草芽孢杆菌tagAB和tagDEF表达的分析确定了PhoP-P的阻遏作用。
J Bacteriol. 1998 Feb;180(3):753-8. doi: 10.1128/JB.180.3.753-758.1998.
5
Bacillus subtilis PhoP binds to the phoB tandem promoter exclusively within the phosphate starvation-inducible promoter.枯草芽孢杆菌PhoP仅在磷酸盐饥饿诱导型启动子内与phoB串联启动子结合。
J Bacteriol. 1997 Oct;179(20):6302-10. doi: 10.1128/jb.179.20.6302-6310.1997.
6
The pst operon of Bacillus subtilis has a phosphate-regulated promoter and is involved in phosphate transport but not in regulation of the pho regulon.枯草芽孢杆菌的pst操纵子有一个受磷酸盐调节的启动子，参与磷酸盐转运，但不参与pho调控子的调节。
J Bacteriol. 1997 Apr;179(8):2534-9. doi: 10.1128/jb.179.8.2534-2539.1997.
7
Influence of Bacillus subtilis phoR on cell wall anionic polymers.枯草芽孢杆菌phoR对细胞壁阴离子聚合物的影响。
Microbiology (Reading). 1997 Mar;143 ( Pt 3):947-956. doi: 10.1099/00221287-143-3-947.
8
Three two-component signal-transduction systems interact for Pho regulation in Bacillus subtilis.在枯草芽孢杆菌中，三个双组分信号转导系统相互作用以调控 Pho 。
Mol Microbiol. 1996 Mar;19(5):941-8. doi: 10.1046/j.1365-2958.1996.422952.x.
9
The signal-transduction network for Pho regulation in Bacillus subtilis.枯草芽孢杆菌中 Pho 调控的信号转导网络。
Mol Microbiol. 1996 Mar;19(5):933-9. doi: 10.1046/j.1365-2958.1996.421953.x.
10
A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.一种枯草芽孢杆菌分泌的磷酸二酯酶/碱性磷酸酶是Pho调节子基因phoD的产物。
Microbiology (Reading). 1996 Aug;142 ( Pt 8):2041-7. doi: 10.1099/13500872-142-8-2041.

Pho-P在枯草芽孢杆菌细胞壁阴离子聚合物生物合成相关基因转录调控中的作用

Role of Pho-P in transcriptional regulation of genes involved in cell wall anionic polymer biosynthesis in Bacillus subtilis.

作者信息

Qi Y, Hulett F M

机构信息

Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois 60607, USA.

出版信息

J Bacteriol. 1998 Aug;180(15):4007-10. doi: 10.1128/JB.180.15.4007-4010.1998.

DOI:10.1128/JB.180.15.4007-4010.1998
PMID:9683503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC107390/
Abstract

tagA, tagD, and tuaA operons are responsible for the synthesis of cell wall anionic polymer, teichoic acid, and teichuronic acid, respectively, in Bacillus subtilis. Under phosphate starvation conditions, teichuronic acid is synthesized while teichoic acid synthesis is inhibited. Expression of these genes is controlled by PhoP-PhoR, a two-component system. It has been proposed that Pho-P plays a key role in the activation of tuaA and the repression of tagA and tagD. In this study, we demonstrated the role of Pho-P in the switch process from teichoic acid synthesis to teichuronic acid synthesis, by using an in vitro transcription system. The results indicate that PhoP approximately P is sufficient to repress the transcription of the tagA and tagD promoters and also to activate the transcription of the tuaA promoter.

摘要

在枯草芽孢杆菌中，tagA操纵子、tagD操纵子和tuaA操纵子分别负责细胞壁阴离子聚合物、磷壁酸和磷壁醛酸的合成。在磷酸盐饥饿条件下，会合成磷壁醛酸，同时抑制磷壁酸的合成。这些基因的表达受双组分系统PhoP-PhoR调控。有人提出，Pho-P在激活tuaA以及抑制tagA和tagD中起关键作用。在本研究中，我们通过使用体外转录系统证明了Pho-P在从磷壁酸合成到磷壁醛酸合成的转换过程中的作用。结果表明，PhoP-PhoR足以抑制tagA和tagD启动子的转录，也足以激活tuaA启动子的转录。