Jacquemin C, Karcioglu Z A
King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.
Eye (Lond). 1998;12 ( Pt 2):179-83. doi: 10.1038/eye.1998.44.
The study was designed to evaluate the value of enhanced computed tomography (CT) as a non-invasive test in the detection of optic nerve invasion in retinoblastoma.
Nineteen eyes in 17 consecutive retinoblastoma patients underwent CT studies performed with high spatial resolution (512 x 512) and 1.5 mm sections, both with enhancement and without enhancement. If the central retinal vessels (CRV) were subjectively visualised with intravenous enhancement, the optic nerve was considered to be free of retinoblastoma. Nineteen enucleated globes were processed for histopathology, and the optic disc and nerve examined with light microscopy for the presence or absence of tumour and the level of involvement.
The correlation between the visualisation of CRV and the presence or absence of optic nerve involvement histopathologically was found to be highly significant (p = 0.0006, Fisher exact test).
In high spatial resolution CT with enhancement and 1.5 mm or thinner sections, non-visualisation of the CRV appears to be a reliable indicator of optic nerve invasion with retinoblastoma.
本研究旨在评估增强计算机断层扫描（CT）作为一种非侵入性检查在检测视网膜母细胞瘤视神经侵犯中的价值。
对17例连续的视网膜母细胞瘤患者的19只眼睛进行了CT检查，采用高空间分辨率（512×512）和1.5毫米层厚，包括增强扫描和非增强扫描。如果在静脉增强扫描时能主观看到视网膜中央血管（CRV），则认为视神经未受视网膜母细胞瘤侵犯。对19只摘除的眼球进行组织病理学处理，用光镜检查视盘和神经有无肿瘤及受累程度。
发现CRV的显影与组织病理学上视神经是否受累之间的相关性非常显著（p = 0.0006，Fisher精确检验）。
在增强扫描且层厚为1.5毫米或更薄的高空间分辨率CT中，CRV不显影似乎是视网膜母细胞瘤视神经侵犯的可靠指标。
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