College of Pharmacy and Pharmaceutical Sciences, The University of Toledo Health Science Campus, Toledo, OH, 43614, USA.
Principal Scientist, Par Pharmaceuticals, 1 Ram Ridge Rd, Spring Valley, New York, 10977, USA.
AAPS J. 2018 Sep 5;20(6):97. doi: 10.1208/s12248-018-0259-9.
Different types of imaging modalities are used in the diagnosis of ocular cancer. Selection of an imaging modality is based on the features of a tumor as well as the inherent characteristics of the imaging technique. It is vital to select an appropriate imaging modality in diagnosis of ocular tumor with confidence. This review focuses on five most commonly used imaging modalities, i.e., positron emission tomography-computed tomography (PET/CT), single photon emission computed tomography (SPECT), optical coherence tomography (OCT), ultrasound (US), and magnetic resonance imaging (MRI). The principal of imaging modalities is briefly explained, along with their role in the diagnosis and management of the most common ocular tumors such as retinoblastoma and uveal melanoma. Further, the diagnostic features of ocular tumors corresponding to each imaging modality and possibilities of utilizing imaging techniques in the process of ocular drug development are included in this review.
不同类型的成像方式用于眼部癌症的诊断。成像方式的选择基于肿瘤的特征以及成像技术的固有特性。在诊断眼部肿瘤时,有信心选择适当的成像方式至关重要。这篇综述重点介绍了五种最常用的成像方式,即正电子发射断层扫描-计算机断层扫描(PET/CT)、单光子发射计算机断层扫描(SPECT)、光学相干断层扫描(OCT)、超声(US)和磁共振成像(MRI)。简要解释了成像方式的原理,并介绍了它们在诊断和管理最常见的眼部肿瘤(如视网膜母细胞瘤和葡萄膜黑色素瘤)中的作用。此外,本文还包括了每种成像方式对应的眼部肿瘤的诊断特征,以及在眼部药物开发过程中利用成像技术的可能性。