Torchio M, Battista S, Bar F, Molino G
Azienda Ospedaliera San Giovanni Battista di Torino, Divisione di Medicina Generale A e Laboratorio di Informatica Clinica, Italy.
Comput Biol Med. 1998 Mar;28(2):91-104. doi: 10.1016/s0010-4825(98)00002-x.
In this study a mathematical model was applied to predict how changes in hepatic extraction ratio (E), fractional portal inflow (P) and renal elimination ratio (R) may affect fractional D-sorbitol bioavailability in cirrhotic patients. D-sorbitol bioavailability was computed as the ratio between cumulative urinary outputs measured after infusion into the superior mesenteric (Uma) or the hepatic artery (Uha) and a systemic vein (Usv). The present work was aimed at explaining by mathematical simulation the very large difference observed in the regression lines when plotting Uma or Uha against Usv values. The study was performed by considering a pathophysiological model of the hepatic circulation and simulating independent variations of the above considered parameters or assuming particular pathophysiological conditions like hepatic arterialization and hepatofugal flow. Computational results account for the wide dispersion of experimental data obtained in previous studies and provide reasonable explanations of unexpected findings.
在本研究中，应用数学模型来预测肝提取率（E）、门静脉血流分数（P）和肾清除率（R）的变化如何影响肝硬化患者中D - 山梨醇的生物利用度分数。D - 山梨醇生物利用度计算为经肠系膜上静脉（Uma）或肝动脉（Uha）注入后测得的累积尿量与体静脉（Usv）累积尿量之比。本研究旨在通过数学模拟解释在绘制Uma或Uha与Usv值的回归线时观察到的巨大差异。该研究通过考虑肝循环的病理生理模型并模拟上述参数的独立变化或假设特定的病理生理状况（如肝动脉化和肝外分流）来进行。计算结果解释了先前研究中获得的实验数据的广泛分散性，并为意外发现提供了合理的解释。
