Hanazaki K, Kawamura N, Wakabayashi M, Sodeyama H, Yokoyama S, Sode Y, Miyazaki T
Department of Surgery, Nagano Red Cross Hospital, Japan.
Hepatogastroenterology. 1998 May-Jun;45(21):816-20.
A 58-year-old man who had rectal cancer with synchronous hepatic metastases of bilateral lobe is described in this case report. Anterior resection for rectal cancer was performed, and subsequent hepatic arterial infusion (HAI) chemotherapy for liver metastases was continued. Nine months later, although right hepatic metastases showed complete remission after chemotherapy, metastases of the left lateral segment were still remained. Left lateral segmentectomy of the liver was performed. HAI chemotherapy has continued for 17 months after hepatectomy to prevent intrahepatic recurrence of the tumor. The patient has been no evidence of recurrence including hepatic metastasis, and he is still doing well 8 years after initial HAI chemotherapy. A review of the literature reveals that this patient has survived longer than any other patient has with hepatic metastases from colorectal cancer treated by this approach. We suggest that this form of therapy should be considered for future patients.
本病例报告描述了一名58岁患有直肠癌且双侧肝叶同时发生肝转移的男性患者。对直肠癌进行了前切除术，并继续对肝转移灶进行肝动脉灌注（HAI）化疗。9个月后，尽管化疗后右肝转移灶完全缓解，但左外叶转移灶仍然存在。遂进行了左外叶肝切除术。肝切除术后继续进行HAI化疗17个月以预防肿瘤肝内复发。该患者无复发迹象，包括肝转移，自初始HAI化疗后8年仍状况良好。文献回顾显示，该患者的存活时间比采用这种方法治疗的其他任何结直肠癌肝转移患者都要长。我们建议未来的患者应考虑这种治疗方式。
