Bruno D W, Griffiths J, Mitchell C G, Wood B P, Fletcher Z J, Drobniewski F A, Hastings T S
FRS Marine Laboratory, Aberdeen, Scotland, UK.
Dis Aquat Organ. 1998 Jun 19;33(2):101-9. doi: 10.3354/dao033101.
This study was promoted following concern over increasing mortality on 2 farms rearing Atlantic salmon Salmo salar in the Shetland Isles, Scotland. A Mycobacterium sp. was isolated from moribund, market-sized Atlantic salmon. Biochemical tests, lipid analysis and PCR (polymerase chain reaction) techniques confirmed the bacterium to be Mycobacterium chelonae. Multiple greyish-white miliary granuloma-like nodules were observed in several tissues. Dense hard-packed nodules contained abundant acid-fast bacteria. Atlantic salmon injected with M. chelonae remained sub-clinically infected, demonstrating the chronic nature of this disease. The source of the pathogen was not identified.
在苏格兰设得兰群岛,两个养殖大西洋鲑(Salmo salar)的养殖场死亡率不断上升,引发了人们的关注,在此背景下开展了本研究。从濒死的、达到上市规格的大西洋鲑中分离出一株分枝杆菌属细菌。生化试验、脂质分析和聚合酶链反应(PCR)技术证实该细菌为龟分枝杆菌(Mycobacterium chelonae)。在多个组织中观察到多个灰白色粟粒状肉芽肿样结节。密集紧实的结节中含有大量抗酸菌。注射了龟分枝杆菌的大西洋鲑仍处于亚临床感染状态,表明该病具有慢性特征。病原体来源未明确。