Príborský J, Kikuchi K, Takayama K, Nagai T
Glaxo Wellcome s.r.o., Prague, Czech Republic.
Acta Univ Palacki Olomuc Fac Med. 1998;141:31-3.
Promoting effect of cyclic monoterpenes on percutaneous absorption of antiarrythmics drugs disopyramide, lidocaine and trimecaine was investigated in the rats. Laurocapram (Azone) was used as a standard comparator of penetration enhancement. The absorption of trimecaine was significantly enhanced by addition of limonene, trans-p-menthane and Azone in 1% concentration. Lidocaine and disopyramide penetrated across the skin only when 1% of limonene was used. Other cyclic monoterpenes showed no effect on percutaneous absorption of examined drugs.
研究了环状单萜对大鼠抗心律失常药物双异丙吡胺、利多卡因和三甲卡因经皮吸收的促进作用。月桂氮卓酮（氮酮）用作渗透促进的标准对照物。添加1%浓度的柠檬烯、反式对薄荷烷和氮酮可显著增强三甲卡因的吸收。仅当使用1%的柠檬烯时，利多卡因和双异丙吡胺才能透过皮肤。其他环状单萜对所检测药物的经皮吸收无影响。
