Spady DW, Saunders LD, Bamforth F
Departments of Pediatrics, Faculty of Medicine.
Pediatrics. 1998 Aug;102(2):E21A.
Objective. To determine reasons for and adequacy of follow-up testing of suspect results of metabolic screening in infants born in Alberta in 1992. Study Design. Of 42 392 live births, 41 553 infants were deterministically matched using birth registry data. Infants requiring repeat analyses were determined from notes made on the screening report. Characteristics of infants needing repeat screening, and obtaining a repeat screen results, were determined by logistic regression using variables from the birth registry and the screening record. Results. A total of 1375 infants required repeat screening. Infants with unsatisfactory samples were more likely to be born in a smaller community, of low birth weight, and to have the sample obtained after 7 days of age. Infants with biologically suspect results were more likely to be of low birth weight, to die in week 1 of life, and to be born in a large hospital. Repeat analyses were found for 663 infants. Boys, infants from smaller communities, and low birth weight infants were more likely to have the required repeat screening. Infants of single mothers were less likely to undergo repeat screening. Conclusions. The results of this study demonstrate the need for a clear, time-oriented protocol of follow-up of newborn metabolic screening results.
目的。确定1992年在艾伯塔省出生的婴儿代谢筛查可疑结果的随访检测原因及充分性。研究设计。在42392例活产婴儿中，利用出生登记数据对41553例婴儿进行确定性匹配。根据筛查报告上的记录确定需要重复分析的婴儿。通过使用出生登记和筛查记录中的变量进行逻辑回归，确定需要重复筛查并获得重复筛查结果的婴儿的特征。结果。共有1375例婴儿需要重复筛查。样本不合格的婴儿更有可能出生在较小社区，出生体重低，且样本在出生7天后采集。生物学上可疑结果的婴儿更有可能出生体重低，在出生后第一周死亡，且出生在大型医院。为663例婴儿进行了重复分析。男孩、来自较小社区的婴儿和低体重婴儿更有可能进行所需的重复筛查。单身母亲的婴儿进行重复筛查的可能性较小。结论。本研究结果表明，需要有一个明确的、以时间为导向的新生儿代谢筛查结果随访方案。
