Vereczkey L, Klátyilc M, Bárdosi Z, Jemnitz K, Vékey K
Magyar Tudományos Akadémia, Központi Kémiai Kutató Intézet, Budapest.
Orv Hetil. 1998 Jul 5;139(27):1639-42.
A 17 years old male patient with Pyrimethamin therapy was released from our department by emphasising the necessity of continuous control. A month later the patient was accepted again with serious anaemia. Since the patient did not follow the instructions Pyrimethamin intoxication was presumed, but it had to be proved. At last the drug in the plasma was identified and quantified by mass spectrometry. The plasma concentration of Pyrimethamin was five times higher than the therapeutic level. The rapid analysis (4 hours after taking of blood) and adequate treatment resulted in rapid improvement with the concomitant decrease of plasma Pyrimethamin concentration. During clinical treatment the level of Pyrimethamin in the plasma was followed by mass spectrometry.
一名接受乙胺嘧啶治疗的17岁男性患者在强调持续监测必要性后从我们科室出院。一个月后，该患者因严重贫血再次入院。由于患者未遵循医嘱，推测为乙胺嘧啶中毒，但必须予以证实。最终通过质谱法对血浆中的药物进行了鉴定和定量。乙胺嘧啶的血浆浓度比治疗水平高五倍。快速分析（采血后4小时）和适当治疗使患者迅速好转，同时血浆乙胺嘧啶浓度降低。在临床治疗期间，通过质谱法监测血浆中乙胺嘧啶的水平。
