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Effect of gene transfer of tumor necrosis factor receptors into human lung carcinoma cell line.肿瘤坏死因子受体基因转移对人肺癌细胞系的影响。
Jpn J Cancer Res. 1998 May;89(5):589-95. doi: 10.1111/j.1349-7006.1998.tb03302.x.
2
Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF.转染的人p75肿瘤坏死因子（TNF）受体被触发后，L929小鼠纤维肉瘤细胞中的细胞毒性由内源性小鼠TNF介导。
Cytokine. 1995 Jul;7(5):463-70. doi: 10.1006/cyto.1995.0063.
3
Preferential expression of tumor necrosis factor receptor 55 (TNF-R55) on human articular chondrocytes: selective transcriptional upregulation of TNF-R75 by proinflammatory cytokines interleukin 1beta, tumor necrosis factor-alpha, and basis fibroblast growth factor.肿瘤坏死因子受体55（TNF-R55）在人关节软骨细胞上的优先表达：促炎细胞因子白细胞介素1β、肿瘤坏死因子-α和成纤维细胞生长因子对TNF-R75的选择性转录上调。
J Rheumatol. 1999 Mar;26(3):645-53.
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An apoptosis-inducing gene therapy for pancreatic cancer with a combination of 55-kDa tumor necrosis factor (TNF) receptor gene transfection and mutein TNF administration.一种用于胰腺癌的凋亡诱导基因疗法，联合55 kDa肿瘤坏死因子（TNF）受体基因转染和突变型TNF给药。
Cancer Res. 1998 Apr 15;58(8):1677-83.
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Dimerization of chimeric erythropoietin/75 kDa tumour necrosis factor (TNF) receptors transduces TNF signals: necessity for the 75 kDa-TNF receptor transmembrane domain.嵌合型促红细胞生成素/75 kDa肿瘤坏死因子（TNF）受体的二聚化转导TNF信号：75 kDa - TNF受体跨膜结构域的必要性。
Cytokine. 1995 Oct;7(7):701-9. doi: 10.1006/cyto.1995.0082.
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Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.两种肿瘤坏死因子受体在诱导细胞凋亡中的协同作用：肿瘤坏死因子受体75的肿瘤坏死因子受体相关因子结合结构域的参与。
J Immunol. 1998 Jul 1;161(1):390-9.
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Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.TNF介导的PC60细胞凋亡诱导需要两种TNF受体。
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TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptor.肿瘤坏死因子诱导贴壁人中性粒细胞产生超氧阴离子涉及p55和p75两种肿瘤坏死因子受体。
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Distribution of TNF-alpha, TNF-R55 and TNF-R75 in the rheumatoid synovial membrane: TNF receptors are localized preferentially in the lining layer; TNF-alpha is distributed mainly in the vicinity of TNF receptors in the deeper layers.
Scand J Immunol. 1999 Mar;49(3):278-85. doi: 10.1046/j.1365-3083.1999.00458.x.
10
Soluble tumor necrosis factor receptors in chronic hepatitis C: a correlation with histological fibrosis and activity.慢性丙型肝炎中的可溶性肿瘤坏死因子受体：与组织学纤维化和活性的相关性
J Hepatol. 1999 Feb;30(2):185-91. doi: 10.1016/s0168-8278(99)80060-9.

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Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy.食欲素2受体作为免疫毒素和抗体药物偶联物癌症治疗的潜在靶点。
Oncol Lett. 2012 Mar;3(3):525-529. doi: 10.3892/ol.2011.528. Epub 2011 Dec 19.

本文引用的文献

1
The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.肿瘤坏死因子受体2信号转导分子TRAF2和c-IAP1是肿瘤坏死因子受体1信号复合物的组成成分。
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13973-8. doi: 10.1073/pnas.93.24.13973.
2
Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects.两种肿瘤坏死因子（TNF）受体在调节TNF和淋巴毒素α效应中的不同作用。
J Biol Chem. 1996 Apr 19;271(16):9778-84. doi: 10.1074/jbc.271.16.9778.
3
A novel domain within the 55 kd TNF receptor signals cell death.55千道尔顿肿瘤坏死因子受体中的一个新结构域可引发细胞死亡信号。
Cell. 1993 Sep 10;74(5):845-53. doi: 10.1016/0092-8674(93)90464-2.
4
Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.配体传递：75千道尔顿的肿瘤坏死因子（TNF）受体募集TNF，通过55千道尔顿的TNF受体进行信号传导。
J Biol Chem. 1993 Sep 5;268(25):18542-8.
5
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.缺乏55kd肿瘤坏死因子受体的小鼠对内毒素休克具有抗性，但会死于单核细胞增生李斯特菌感染。
Cell. 1993 May 7;73(3):457-67. doi: 10.1016/0092-8674(93)90134-c.
6
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.可溶性人55kd肿瘤坏死因子受体-人肿瘤坏死因子β复合物的晶体结构：对肿瘤坏死因子受体激活的影响
Cell. 1993 May 7;73(3):431-45. doi: 10.1016/0092-8674(93)90132-a.
7
Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor.肿瘤坏死因子的细胞毒性活性由p55肿瘤坏死因子受体发出信号。
Cell. 1993 Apr 23;73(2):213-6. doi: 10.1016/0092-8674(93)90222-c.
8
Suppression of in vivo tumorigenicity of human lung cancer cells by retrovirus-mediated transfer of the human tumor necrosis factor-alpha cDNA.逆转录病毒介导的人肿瘤坏死因子-α cDNA 转移对人肺癌细胞体内致瘤性的抑制作用
Am J Respir Cell Mol Biol. 1994 Sep;11(3):270-8. doi: 10.1165/ajrcmb.11.3.8086165.
9
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.一个与75 kDa肿瘤坏死因子受体胞质结构域相关的新型假定信号转导分子家族。
Cell. 1994 Aug 26;78(4):681-92. doi: 10.1016/0092-8674(94)90532-0.
10
TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways.肿瘤坏死因子受体TR60和TR80可通过诱导不同的信号通路介导细胞凋亡。
J Immunol. 1994 Sep 1;153(5):1963-72.

肿瘤坏死因子受体基因转移对人肺癌细胞系的影响。

Effect of gene transfer of tumor necrosis factor receptors into human lung carcinoma cell line.

作者信息

Ohara H, Hasegawa Y, Kawabe T, Ichiyama S, Hara T, Shimono Y, Saito H, Shimokata K

机构信息

First Department of Internal Medicine, Nagoya University School of Medicine.

出版信息

Jpn J Cancer Res. 1998 May;89(5):589-95. doi: 10.1111/j.1349-7006.1998.tb03302.x.

DOI:10.1111/j.1349-7006.1998.tb03302.x
PMID:9685865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5921841/
Abstract

The human lung adenocarcinoma cell line A549 is known to be resistant to tumor necrosis factor alpha (TNF-alpha)-mediated tumor cell lysis in spite of the expression of 55 kDa TNF receptor (TNF-R55) mRNA and its cell surface protein. In this study, we investigated the mechanism of TNF-alpha resistance and the role of two types of TNF receptors (TNF-R55 and TNF-R75 (75 kDa TNF receptor)). TNF-R55 or TNF-R75 cDNA was transfected into A549 cells. In addition, a C-terminal deletion mutant of TNF-R75 which lacks the intracellular domain of TNF-R75 was also transfected into A549 cells. We assessed the TNF-alpha-mediated tumor cell lysis of these transfected clones, and found that the cytotoxic effect increased in transfected clones highly expressing TNF- R55, but not in low-expression clones. As for TNF-R75, the cytotoxic effect of TNF-alpha was observed in TNF-R75-transfected clones even when expression was low. Furthermore, the cytotoxic effect was also observed in clones transfected with the deletion mutant of TNF-R75, as well as the complete TNF-R75. These results indicate that a certain level of expression of TNF-R75 is necessary for obtaining TNF-alpha-mediated tumor cell lysis in the absence of TNF-R75. On the other hand, the expression of TNF-R75 strongly induces TNF-alpha-mediated cytotoxicity through TNF-R55 in the absence of an intracellular signal via TNF-R75.

摘要

人肺腺癌细胞系A549尽管表达55 kDa肿瘤坏死因子受体（TNF-R55）mRNA及其细胞表面蛋白，但已知对肿瘤坏死因子α（TNF-α）介导的肿瘤细胞裂解具有抗性。在本研究中，我们研究了TNF-α抗性的机制以及两种类型的TNF受体（TNF-R55和TNF-R75（75 kDa TNF受体））的作用。将TNF-R55或TNF-R75 cDNA转染到A549细胞中。此外，还将缺乏TNF-R75细胞内结构域的TNF-R75 C末端缺失突变体转染到A549细胞中。我们评估了这些转染克隆的TNF-α介导的肿瘤细胞裂解，发现细胞毒性作用在高表达TNF-R55的转染克隆中增加，而在低表达克隆中则没有。至于TNF-R75，即使表达水平较低，在TNF-R75转染的克隆中也观察到TNF-α的细胞毒性作用。此外，在用TNF-R75缺失突变体以及完整的TNF-R75转染的克隆中也观察到了细胞毒性作用。这些结果表明，在没有TNF-R75的情况下，获得TNF-α介导的肿瘤细胞裂解需要一定水平的TNF-R75表达。另一方面，在没有通过TNF-R75的细胞内信号的情况下，TNF-R75的表达通过TNF-R55强烈诱导TNF-α介导的细胞毒性。