[龟分枝杆菌皮肤感染：克拉霉素延长治疗的疗效]
[Mycobacterium chelonae cutaneous infection: efficacy of prolonged treatment by clarithromycin].
作者信息
Bordet A L, Machet L, De Muret A, François-Ramanantsoa C, Lorette G, Vaillant L
机构信息
Service de dermatologie, CHU Trousseau, Tours, France.
出版信息
Ann Dermatol Venereol. 1997;124(3):251-3.
INTRODUCTION
Mycobacterium chelonae is an ubiquitous mycobacterium which is exceptionally pathogenic. It can cause localized skin infections which are difficult to treat because of multiple drug-resistance.
CASE REPORT
A 87-year-old woman with bullous pemphigoid was treated with long-term prednisone and developed a skin infection due to M. Chelonae. Treatment with clarithromycin was successful, but relapse occurred 6 months after withdrawal of the antibiotic.
DISCUSSION
Clarithromycin is effective in single drug regimen for M. Chelonae infection, but the duration of treatment should be long when immunosuppression cannot be avoided.
引言
龟分枝杆菌是一种普遍存在的分枝杆菌，具有极强的致病性。它可引起局部皮肤感染，由于多重耐药性，这种感染难以治疗。
病例报告
一名87岁患有大疱性类天疱疮的女性长期使用泼尼松治疗，并发了由龟分枝杆菌引起的皮肤感染。克拉霉素治疗取得成功，但抗生素停药6个月后复发。
讨论
克拉霉素单药治疗龟分枝杆菌感染有效，但在无法避免免疫抑制的情况下，治疗疗程应延长。
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