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[华氏巨球蛋白血症与脑淋巴浆细胞增殖:宾和尼尔综合征。附1例新病例]

[Waldenström's macroglobulinemia and cerebral lymphoplasmocytic proliferation: Bing and Neel syndrome. Apropos of a new case].

作者信息

Civit T, Coulbois S, Baylac F, Taillandier L, Auque J

机构信息

Service de Neurochirurgie, Hôpital Saint-Julien, CHU, Nancy.

出版信息

Neurochirurgie. 1997;43(4):245-9.

PMID:9686227
Abstract

Waldenström's disease is a B-cell, low grade lymphoma, secreting an immunoglobulin M, and is called immunocytoma. Neurological complications are frequent, but encephalopathies due to lymphoplasmocytoid infiltration are rare (Bing-Neel syndrome). Tumors, probably arising from confluence of infiltrative areas, are exceedingly rare. The authors report the case of a 70-year-old man, suffering from a Waldenström's immunoglobulinemia, who underwent surgery for a right sided rolandic tumor involving the vault, the dura-mater, and the cortex. On the CT scan, the tumor mimicked a meningioma. Histological study and immunohistologic stains confirmed the monoclonal nature of the tumor. Based on the review of the literature, clinical and neuroradiological features of these infiltrative and tumoral rare lesions, as well as their histopathogenesis and treatment, are discussed.

摘要

华氏巨球蛋白血症是一种B细胞低度淋巴瘤,可分泌免疫球蛋白M,也被称为免疫细胞瘤。神经系统并发症很常见,但由淋巴浆细胞样浸润引起的脑病很少见(宾-尼尔综合征)。肿瘤可能由浸润区域融合形成,极为罕见。作者报告了一例70岁男性患者,患有华氏免疫球蛋白血症,因右侧中央前回肿瘤累及颅骨穹窿、硬脑膜和皮质而接受手术。在CT扫描中,该肿瘤类似脑膜瘤。组织学研究和免疫组织化学染色证实了肿瘤的单克隆性质。基于文献回顾,讨论了这些浸润性和肿瘤性罕见病变的临床和神经放射学特征,以及它们的组织发病机制和治疗方法。

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