Schmidt G, Aktories K
Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Germany.
Naturwissenschaften. 1998 Jun;85(6):253-61. doi: 10.1007/s001140050495.
Low molecular mass GTPases of the Rho family, which are involved in the regulation of the actin cytoskeleton and in various signal transduction processes, are the eukaryotic targets of bacterial protein toxins. The toxins covalently modify Rho proteins by ADP ribosylation, glucosylation, and deamidation, thereby inactivating and activating the GTPases.
Rho家族的低分子量GTP酶参与肌动蛋白细胞骨架的调节和各种信号转导过程，是细菌蛋白毒素的真核靶点。这些毒素通过ADP核糖基化、糖基化和脱酰胺作用对Rho蛋白进行共价修饰，从而使GTP酶失活和激活。
