Roliński J, Rupniewska Z M, Wasik-Szczepanek E A
Zakładu Immunologii Klinicznej AM w Lublinie.
Pol Arch Med Wewn. 1998 Jan;99(1):48-55.
CD8 antigen is present on the surface of cytotoxic-suppressor T cells, NK cells and majority of thymocytes. Expression of CD 8 is associated with CD 3 antigen, which is a part of a T cell receptor. However, CD 8 antigen is undetectable on normal B cells. In sporadic cases of B cell-chronic lymphocytic leukaemia (B-CLL) it was found on leukaemic B cells. We report a case of B-CLL of benign course with CD19+, CD5+, CD40+, CD19+, CD20+, CD19+, CD19+HLADR+ leukaemic cells expressing CD8 antigen on CD19+ leukaemic cells. It seems that original neoplasms source was localized out of bone marrow. We suggest that the origin of the target cell for neoplasms transformation could be CD5+ B cell and CD8+ T cell gamma + delta + CD8+.
CD8抗原存在于细胞毒性抑制性T细胞、自然杀伤细胞以及大多数胸腺细胞的表面。CD8的表达与CD3抗原相关，CD3抗原是T细胞受体的一部分。然而，在正常B细胞上检测不到CD8抗原。在散发性B细胞慢性淋巴细胞白血病（B-CLL）病例中，在白血病B细胞上发现了CD8抗原。我们报告了一例病程良性的B-CLL病例，其白血病细胞为CD19+、CD5+、CD40+、CD19+、CD20+、CD19+、CD19+ HLA-DR+，且这些CD19+白血病细胞表达CD8抗原。似乎肿瘤的原始来源定位于骨髓外。我们认为肿瘤转化的靶细胞起源可能是CD5+B细胞和CD8+T细胞γ+δ+CD8+。
