Czermak B J, Friedl H P, Ward P A
Department of Trauma Surgery, University of Freiburg, Freiburg/Breisgau, Germany.
Proc Assoc Am Physicians. 1998 Jul-Aug;110(4):306-12.
Directional emigration of neutrophils is the hallmark of phlogistic processes. The involved regulatory mechanisms include complement activation products, cytokines, adhesion molecules, and their respective counter receptors. In this article, we discuss the role of these mediators in initiation, development, and containment of acute inflammatory responses in in vitro and in vivo models, showing interactions between a network of proinflammatory and anti-inflammatory effectors. A major focus deals with the effects of complement on activation of the vascular endothelium. In addition, the role of interleukins in the regulation of inflammatory responses is described.
中性粒细胞的定向迁移是炎症过程的标志。涉及的调节机制包括补体激活产物、细胞因子、黏附分子及其各自的对应受体。在本文中，我们讨论了这些介质在体外和体内模型中急性炎症反应的起始、发展和控制中的作用，展示了促炎和抗炎效应器网络之间的相互作用。一个主要焦点是补体对血管内皮激活的影响。此外，还描述了白细胞介素在炎症反应调节中的作用。
