Martin S J, Pendland S L
Department of Pharmacy Practice, The University of Toledo, OH 43606, USA.
J Antimicrob Chemother. 1998 Jun;41(6):643-8. doi: 10.1093/jac/41.6.643.
Time-kill curves using simulated peak and trough serum concentrations, and postantibiotic effect (PAE) were determined for clarithromycin and 14-hydroxyclarithromycin alone and in combination against four strains of Legionella pneumophila. Both compounds were bactericidal at both peak and trough concentrations. The combination at trough concentrations demonstrated lower killing activity than the parent drug in three of the four strains. PAE ranges were 7.28-17.3 h for clarithromycin, 6.78-14.77 h for the metabolite, and 5.15-13.23 h for the combination.
采用模拟的血清峰浓度和谷浓度测定了克拉霉素和14-羟基克拉霉素单独及联合使用对四株嗜肺军团菌的时间杀菌曲线及抗生素后效应（PAE）。两种化合物在峰浓度和谷浓度时均具有杀菌作用。在四株菌中的三株中，谷浓度时的联合用药显示出比母体药物更低的杀菌活性。克拉霉素的PAE范围为7.28 - 17.3小时，代谢物的PAE范围为6.78 - 14.77小时，联合用药的PAE范围为5.15 - 13.23小时。
