一个关于通道调节的感人案例：ATP敏感性钾通道。
A touching case of channel regulation: the ATP-sensitive K+ channel.
作者信息
Tucker S J, Ashcroft F M
机构信息
University Laboratory of Physiology, Oxford, UK.
出版信息
Curr Opin Neurobiol. 1998 Jun;8(3):316-20. doi: 10.1016/s0959-4388(98)80055-x.
PMID:9687347
Abstract
The classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of MgADP. Both subunits are required to form a functional channel.
摘要
经典类型的ATP敏感性钾通道（KATP通道）是由两个结构不相关的亚基Kir6.2和磺脲类药物受体（SUR）组成的八聚体（4:4）复合物。前者作为一个ATP抑制性孔道，而SUR是一个调节亚基，赋予对磺酰脲类药物和钾通道开放剂的敏感性，以及MgADP的增强作用。两个亚基都是形成功能性通道所必需的。
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