Zamponi G W, Snutch T P
Department of Pharmacology and Therapeutics, University of Calgary, Canada.
Curr Opin Neurobiol. 1998 Jun;8(3):351-6. doi: 10.1016/s0959-4388(98)80060-3.
Voltage-gated calcium channels are found in all excitable cells, in which they regulate many important physiological functions, including excitability, gene transcription, muscle contraction, and neurotransmitter and hormone release. The differential modulation of calcium channels by intracellular second messengers constitutes a key mechanism for controlling calcium influx. Recent advances have provided important clues to the underlying molecular mechanisms involved in the inhibition of N-type and P/Q-type calcium channels by a membrane-delimited G-protein-dependent pathway.
电压门控钙通道存在于所有可兴奋细胞中，在这些细胞中它们调节许多重要的生理功能，包括兴奋性、基因转录、肌肉收缩以及神经递质和激素释放。细胞内第二信使对钙通道的差异调节构成了控制钙内流的关键机制。最近的进展为膜限定的G蛋白依赖性途径抑制N型和P/Q型钙通道所涉及的潜在分子机制提供了重要线索。
