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6-硝基屈的真菌生物转化

Fungal biotransformation of 6-nitrochrysene.

作者信息

Pothuluri J V, Sutherland J B, Freeman J P, Cerniglia C E

机构信息

National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.

出版信息

Appl Environ Microbiol. 1998 Aug;64(8):3106-9. doi: 10.1128/AEM.64.8.3106-3109.1998.

DOI:10.1128/AEM.64.8.3106-3109.1998
PMID:9687485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC106827/
Abstract

The fungus Cunninghamella elegans was used to biotransform 6-nitrochrysene, a mutagen that is a widespread environmental contaminant. After 6 days, 74% of the 3H-labeled 6-nitrochrysene added had been metabolized to two isomeric sulfate conjugates. These conjugates were separated by high-performance liquid chromatography and identified by UV-visible, 1H nuclear magnetic resonance, and mass spectral techniques as 6-nitrochrysene 1-sulfate and 6-nitrochrysene 2-sulfate.

摘要

线虫状小克银汉霉被用于对6-硝基屈进行生物转化，6-硝基屈是一种诱变剂，也是一种广泛存在的环境污染物。6天后，添加的3H标记的6-硝基屈中有74%已代谢为两种异构硫酸酯共轭物。这些共轭物通过高效液相色谱法分离，并通过紫外可见光谱、1H核磁共振光谱和质谱技术鉴定为6-硝基屈1-硫酸盐和6-硝基屈2-硫酸盐。

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