Furushima H, Niwano S, Chinushi M, Shiba M, Fujita S, Abe A, Ohhira K, Taneda K, Aizawa Y
First Department of Internal Medicine, Niigata University School of Medicine, Japan.
Jpn Heart J. 1998 Mar;39(2):225-33. doi: 10.1536/ihj.39.225.
Two patients with long QT syndrome, who had episodes of syncope, underwent recordings of the monophasic action potential (MAP) from the right ventricle. Intracoronary administration of acetylcholine (ACh) induced prolongation of MAP duration and caused Torsade de Pointes (Tdp) in both patients. In one patient, intravenous atropine administration did not induce any change in MAP duration. In the other patient, ACh was administered after atropine. According to the results of the present study, abnormal regulation of the muscarinic receptor-mediated K-channel may be involved in the mechanism causing prolongation of MAP duration caused by ACh administration.
两名患有长QT综合征且有晕厥发作的患者接受了右心室单相动作电位（MAP）记录。冠状动脉内注射乙酰胆碱（ACh）导致两名患者的MAP持续时间延长并引发尖端扭转型室速（Tdp）。在一名患者中，静脉注射阿托品未引起MAP持续时间的任何变化。在另一名患者中，在注射阿托品后给予ACh。根据本研究结果，毒蕈碱受体介导的钾通道异常调节可能参与了ACh给药导致MAP持续时间延长的机制。
