Conrad R, Schneider G, Textor J, Fimmers R, Sachse A, Schild H H
Radiologische Universitätsklinik Bonn.
Rofo. 1998 Jun;168(6):610-5. doi: 10.1055/s-2007-1015288.
To evaluate the additional effect of bioadhesives in combination with iotrolan and barium as oral contrast media in an animal model.
The bioadhesives Noveon, CMC, Tylose and Carbopol 934 were added to iotrolan and barium. The solutions were administered to rabbits by a feeding tube. The animals were investigated by computed tomography (CT) and radiography after 0.5, 4, 12, 24 and in part after 48 hours. Mucosal coating and contrast filling of the bowel were evaluated.
Addition of bioadhesives to oral contrast media effected long-term contrast in the small intestine and colon, but no improvement in continuous filling and coating of the gastrointestinal tract was detected. Mucosal coating was seen only in short regions of the caecum and small intestine. In CT the best results for coating were observed with tylose and CMC, in radiography additionally with carbopol and noveon. All contrast medium were well tolerated.
The evaluated contrast medium solutions with bioadhesives have shown long-term contrast but no improvement in coating in comparison to conventional oral contrast media.
在动物模型中评估生物黏附剂与碘曲仑和钡联合作为口服造影剂的附加效果。
将生物黏附剂诺维酮、羧甲基纤维素、羟丙基甲基纤维素和卡波姆934添加到碘曲仑和钡中。通过饲管将溶液给予兔子。在0.5、4、12、24小时以及部分在48小时后通过计算机断层扫描（CT）和X线摄影对动物进行检查。评估肠道的黏膜覆盖和造影剂充盈情况。
向口服造影剂中添加生物黏附剂可在小肠和结肠中实现长期造影，但未检测到胃肠道连续充盈和覆盖情况的改善。仅在盲肠和小肠的短区域可见黏膜覆盖。在CT中，羟丙基甲基纤维素和羧甲基纤维素的覆盖效果最佳，在X线摄影中，卡波姆和诺维酮的效果也较好。所有造影剂耐受性良好。
与传统口服造影剂相比，评估的含生物黏附剂的造影剂溶液显示出长期造影效果，但在覆盖方面没有改善。
