Popovici D, Stan I
Endocrinologie. 1976 Jul-Sep;14(3):219-28.
The diagnosis of pheochromocytoms is still made only post mortem in a high percentage of the cases. It is important to know both the diversity of clinical forms (of the 16 cases investigated 13 (80%) presented permanent AH, of which 12 cases with paroxysmal attacks, followed by collapse only in one case, and 3 (20%) with paroxysmal AH on a normotensive background) and the severity of cardiovascular accidents, which increases twofold during crises (arrhythmias, left ventricular failure, coronary insufficiency, cerebrovascular strokes, secondary adrenalinic shocks). These complications are preceded by the "alarm syndrome". The preoperatory treatment is associated: blocking of adrenergic alpha-receptors and beta-receptors; correction of hypovolemia, also applied during the surgical phase I (until the venous ligature is made and the tumor excised) under continuous monitoring (ECG, ABP and central venous pressure). In phase II vasoplegin should be promptly corrected by nor. E+E, and corticoids.
嗜铬细胞瘤的诊断在很多病例中仍只能在尸检时才能做出。了解临床症状的多样性(在所研究的16例病例中,13例(80%)表现为持续性高血压,其中12例伴有阵发性发作,仅1例随后出现虚脱,3例(20%)在血压正常的背景下出现阵发性高血压)以及心血管意外的严重程度很重要,在发作期间其严重程度会增加两倍(心律失常、左心室衰竭、冠状动脉供血不足、脑血管意外、继发性肾上腺素能休克)。这些并发症之前会出现“警报综合征”。术前治疗包括:阻断肾上腺素能α受体和β受体;纠正血容量不足,在手术第一阶段(直到结扎静脉并切除肿瘤)也应在持续监测(心电图、动脉血压和中心静脉压)下进行。在第二阶段,应通过去甲肾上腺素+肾上腺素和皮质类固醇迅速纠正血管麻痹。