Bove K E, Blough R I, Soukup S
Division of Pathology, Children's Hospital Research Foundation, HT-4, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Pediatr Dev Pathol. 1998 Sep-Oct;1(5):438-42. doi: 10.1007/s100249900060.
We report the third known case of mesenchymal hamartoma of the liver (MHL) with a balanced translocation involving a common breakpoint, 19q13.4. A common clonal chromosome abnormality appears to characterize an important subset of MHL, some of which may be low-grade neoplasms. We found no consistent karyotype abnormality in a post-treatment sample of embryonal sarcoma of the liver (ESL). Reports of coexistent MHL and ESL in two patients and detection of 19q abnormalities in two ESLs appear to support Stocker's hypothesis of a histogenetic link between these two rare liver lesions. More data are needed to clarify this relationship. It is possible that MHLs are etiologically heterogenous and may be developmental disorders, disruptions, or neoplasms.
我们报告了第三例已知的肝脏间叶性错构瘤（MHL），其具有涉及常见断点19q13.4的平衡易位。一种常见的克隆性染色体异常似乎是MHL一个重要亚组的特征，其中一些可能是低级别肿瘤。我们在肝胚胎性肉瘤（ESL）的治疗后样本中未发现一致的核型异常。两名患者中同时存在MHL和ESL以及在两个ESL中检测到19q异常的报告似乎支持了斯托克关于这两种罕见肝脏病变之间存在组织发生学联系的假说。需要更多数据来阐明这种关系。MHL在病因上可能是异质性的，可能是发育障碍、发育中断或肿瘤。
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