RNA聚合酶III转录起始因子IIIB的招募后功能。
A post-recruitment function for the RNA polymerase III transcription-initiation factor IIIB.
作者信息
Kassavetis G A, Kumar A, Letts G A, Geiduschek E P
机构信息
Department of Biology and Center for Molecular Genetics, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0634, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9196-201. doi: 10.1073/pnas.95.16.9196.
Abstract
Transcription factor (TF) IIIB, which directs RNA polymerase (pol) III to its promoters, is made up of three components: the TATA box-binding protein, the TFIIB-related Brf, and the pol III-specific B". Certain mutations in Saccharomyces cerevisiae Brf and B" retain TFIIIB transcription factor activity with supercoiled DNA but are inactive with linear duplex DNA. Further analysis shows that these inactive TFIIIB-DNA complexes bind pol III and position it appropriately over the transcriptional start site but do not form DNA strand-separated open promoter complexes. It is proposed that the normal function of TFIIIB combines pol III recruitment with an active role in a subsequent step of transcriptional initiation leading to promoter opening.
摘要
转录因子（TF）IIIB可将RNA聚合酶（pol）III导向其启动子，它由三个组分组成：TATA框结合蛋白、TFIIB相关的Brf以及pol III特异性的B"。酿酒酵母Brf和B"中的某些突变在超螺旋DNA存在时保留TFIIIB转录因子活性，但在线性双链DNA存在时无活性。进一步分析表明，这些无活性的TFIIIB-DNA复合物可结合pol III并将其正确定位在转录起始位点上方，但不会形成DNA链分离的开放启动子复合物。有人提出，TFIIIB 的正常功能是将pol III募集与转录起始后续步骤中导致启动子开放的积极作用相结合。
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