Doak S M, Simpson B J, Hunt P F, Stevenson D E
Toxicology. 1976 Aug-Sep;6(2):139-54. doi: 10.1016/0300-483x(76)90016-0.
The carcinogenic effects of limited and repeated skin applications of propane sultone were investigated in three strains of mice, CF1, C3H and CBah (a hairless strain). Propane sultone was shown to be carcinogenic when given as a single application of a 25% w/v solution in toluene and also following twice weekly application of a 2.5% w/v solution for up to 58 weeks. More limited exposure to 2.5% w/v solutions of propane sultone resulted in a few skin tumours, although the incidences were not statistically significant. Most neoplasms were papillomas or carcinomas, although a small number of mesenchymal tumours of dermal origin also developed. No skin neoplasms were found in any control mice. The skin application of propane sultone was associated with a statistically significant increase in the incidence of systematic neoplasia in CFl and C3H mice. The exposed CFl mice had a higher incidence of neoplasms of lymphoreticular and lung origin, while female C3H mice showed a higher incidence of mammary gland and uterine tumours. In mice exposed to beta-propiolactone as a positive control, neoplasms developed at the site of application but, there was no evidence of increased systemic neoplasis in contrast to the findings with ptopane sultone.
在CF1、C3H和CBah（一种无毛品系）三种品系的小鼠中，研究了有限次数重复经皮肤涂抹丙烷磺内酯的致癌作用。当以25%（w/v）的甲苯溶液单次涂抹，以及每周两次涂抹2.5%（w/v）的溶液持续58周时，丙烷磺内酯显示出致癌性。对2.5%（w/v）丙烷磺内酯溶液的接触更为有限，虽有少数皮肤肿瘤出现，但发生率无统计学意义。大多数肿瘤为乳头状瘤或癌，不过也有少数起源于真皮的间叶组织肿瘤发生。在任何对照小鼠中均未发现皮肤肿瘤。在CF1和C3H小鼠中，经皮肤涂抹丙烷磺内酯与系统性肿瘤发生率的统计学显著增加相关。暴露的CF1小鼠发生淋巴网状组织和肺部肿瘤的发生率更高，而雌性C3H小鼠乳腺和子宫肿瘤的发生率更高。作为阳性对照，暴露于β-丙内酯的小鼠在涂抹部位出现肿瘤，但与丙烷磺内酯的研究结果相反，没有证据表明系统性肿瘤增加。
