Brzezinski A
Department of Obstetrics and Gynecology, Hebrew University Hadassah Medical School, Jerusalem, Israel.
Menopause. 1998 Spring;5(1):60-4.
Aging, sleep, and breast cancer are important concerns of postmenopausal women. There now is evidence that melatonin, the hormone secreted by the pineal gland, may have a role in the regulation of various human biological processes including sleep, tumor growth, and perhaps aging. The current knowledge concerning these questions is briefly and critically reviewed.
Melatonin might be implicated in menopause-associated processes such as insomnia, breast cancer, and general aging. Its beneficial effect on sleep has been demonstrated in controlled clinical trials, however, "melatonin replacement therapy" for all postmenopausal women is currently unjustified.
衰老、睡眠和乳腺癌是绝经后女性关注的重要问题。目前有证据表明，松果体分泌的褪黑素可能在调节包括睡眠、肿瘤生长以及可能的衰老在内的各种人类生物过程中发挥作用。本文对有关这些问题的现有知识进行了简要且批判性的综述。
褪黑素可能与绝经相关的过程有关，如失眠、乳腺癌和全身衰老。其对睡眠的有益作用已在对照临床试验中得到证实，然而，目前对所有绝经后女性进行“褪黑素替代疗法”是不合理的。
