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氚标记胸腺嘧啶核苷对细胞群体动力学的影响。

Effects of tritiated thymidine on cell population kinetics.

作者信息

Thiessen G, Thiessen H

出版信息

Strahlentherapie. 1976 Sep;152(3):273-84.

PMID:968927
Abstract

This paper reports growth-kinetic data of Chinese Hamster tissue culture cells exposed at various times to differnt activities (0.05 muCi/ml up to 10.0 muCi/ml of tritiated thymidine. The analysis of the results aims at the determination of colony-size distribution and to the cellular capacity of reproduction after treatment which is reflected in the cell division spectrum within dialy intervals. The results of the growth-curves represented were converted into integrated curves of colony-size distribution, and their alteration as exponential curves for estimation of the cell cycle as a function of culture time was established. The recovery process and course determination of population kinetics following the 3H-TdR-treatments were evaluated.

摘要

本文报道了中国仓鼠组织培养细胞在不同时间暴露于不同活性(0.05微居里/毫升至10.0微居里/毫升的氚标记胸腺嘧啶核苷)下的生长动力学数据。结果分析旨在确定集落大小分布以及处理后细胞的繁殖能力,这在每日间隔的细胞分裂谱中有所体现。所呈现的生长曲线结果被转换为集落大小分布的积分曲线,并确定了它们作为指数曲线的变化,以估计细胞周期作为培养时间的函数。评估了3H-TdR处理后群体动力学的恢复过程和进程确定。

相似文献

1
Effects of tritiated thymidine on cell population kinetics.氚标记胸腺嘧啶核苷对细胞群体动力学的影响。
Strahlentherapie. 1976 Sep;152(3):273-84.
2
[Effect of various concentrations of 3H-thymidine on the kinetics of Chinese hamster cell division].[不同浓度的3H-胸腺嘧啶核苷对中国仓鼠细胞分裂动力学的影响]
Med Radiol (Mosk). 1985 Jul;30(7):50-4.
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Nutritional folate deficiency in Chinese hamster ovary cells. I. Characterization of the pleiotropic response and its modulation by nucleic acid precursors.中国仓鼠卵巢细胞中的营养性叶酸缺乏。I. 多效性反应的特征及其被核酸前体的调节。
J Cell Physiol. 1989 Aug;140(2):335-43. doi: 10.1002/jcp.1041400220.
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The effect of 3H-thymidine on the proliferation of in vitro cultured mammalian cells.3H-胸腺嘧啶核苷对体外培养的哺乳动物细胞增殖的影响。
Gen Physiol Biophys. 1985 Feb;4(1):81-92.
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X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells.培养的中国仓鼠细胞在细胞生成周期中的X射线敏感性。
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[Reproductive death and population kinetics of survived hamster cells in vitro during 48 hours following x-ray doses up to 800 Rad. II].[高达800拉德X射线照射后48小时内体外存活仓鼠细胞的生殖死亡和群体动力学。II]
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