Maynou C, Mestdagh H, Beltrand E, Petroff E, Dubois H
Service d'Orthopédie Traumatologie D, CHRU de Lille, France.
Acta Orthop Belg. 1998 Jun;64(2):193-200.
Five patients with a large defect in the articular cartilage at the knee joint were treated by transplantation of an autogenic osteochondral fragment. The graft was harvested from the posterior portion of the ipsilateral femoral condyle in 4 cases of osteochondritis dissecans, and from the lateral third of the patella pedicled on the patellar ligament in one case of posttraumatic necrotic collapse of the lateral tibial plateau. One patient underwent concomitant high tibial osteotomy. Two months postoperatively bony union was achieved in all cases but in one case, the grafted articular cartilage did not survive after weight bearing because of an overlooked varus deformity. At the follow-up examination (8 to 20 years) all 5 patients were asymptomatic ; the range of flexion was somewhat restricted (120 degrees) ; roentgenogram revealed slight narrowing of the articular space or at least flattening of the grafted zone and subchondral osteosclerosis. At arthroscopic exploration, the grafted zones were recognizable from the surrounding cartilage, and histologic examination of their border revealed fibrocartilage and proliferating vessels; late gonarthrosis might ensue over time. Therefore the procedure should be performed only in large osteochondral defects where neither reattachment of a loose body, nor hemiarthroplasty, nor isolated osteotomy are suitable and before degenerative changes have developed. Morever any associated varus deformity requires concomitant correction by high tibial osteotomy to relieve stress from the graft.
5例膝关节软骨大面积缺损患者接受了自体骨软骨碎片移植治疗。4例剥脱性骨软骨炎患者的移植物取自同侧股骨髁后部,1例创伤后外侧胫骨平台坏死塌陷患者的移植物取自以髌韧带为蒂的髌骨外侧三分之一处。1例患者同时接受了高位胫骨截骨术。术后2个月,所有病例均实现了骨愈合,但有1例患者因术前漏诊的内翻畸形,负重后移植的关节软骨未能存活。随访检查(8至20年)时,所有5例患者均无症状;屈曲范围有所受限(120度);X线片显示关节间隙略有变窄,或至少移植区变平,以及软骨下骨硬化。关节镜探查时,移植区可与周围软骨区分开,其边界的组织学检查显示为纤维软骨和增生血管;随着时间推移可能会发生晚期膝关节炎。因此,该手术仅应在既不适合游离体重新附着、半关节置换,也不适合单纯截骨的大面积骨软骨缺损且尚未出现退行性改变时进行。此外,任何相关的内翻畸形都需要通过高位胫骨截骨术进行矫正,以减轻移植物的压力。