Yoshida D, Harashima K, Node Y, Kojima T, Shimura T, Teramoto A
Department of Neurosurgery, Nippon Medical School, Tokyo.
Neurol Med Chir (Tokyo). 1998 Jun;38(6):359-62. doi: 10.2176/nmc.38.359.
Malignant fibrous histiocytomas (MFHs) are mesenchymal tumors, usually arising in soft tissue of the extremities and are remarkably resistant to radiation and chemotherapy. A 45-year-old female presented with a rare case of MFH originating in the cranial bone manifesting as a lump in the left parietal region with no neurological abnormality. Neuroimaging revealed the presence of an osteolytic tumor in the left parietal bone invading into muscle and subdural region, penetrating through the dura. Selective external carotid angiography disclosed a marked tumor stain. Examination of the whole body excluded neoplastic disease elsewhere. The patient was treated by surgical excision, radiation, and two courses of multi-drug chemotherapy using cyclophosphamide, doxorubicin, vincristine, and prednisolone. Since there is no established treatment against this malignancy, a longer follow-up is necessary to determine whether cure has been achieved.
恶性纤维组织细胞瘤（MFH）是间叶组织肿瘤，通常发生于四肢软组织，对放疗和化疗具有显著抗性。一名45岁女性出现了罕见的起源于颅骨的MFH病例，表现为左侧顶叶区域的肿块，无神经功能异常。神经影像学检查显示左侧顶骨有一个溶骨性肿瘤，侵入肌肉和硬膜下区域，并穿透硬脑膜。选择性颈外动脉血管造影显示有明显的肿瘤染色。全身检查排除了其他部位的肿瘤性疾病。该患者接受了手术切除、放疗以及使用环磷酰胺、阿霉素、长春新碱和泼尼松龙进行的两个疗程的多药化疗。由于针对这种恶性肿瘤尚无既定的治疗方法，因此需要更长时间的随访来确定是否已治愈。
