子宫内膜异位症女性的骨密度

Bone density in women with endometriosis.

作者信息

Colacurci N, De Seta L, Passaro M, Scala P, De Franciscis P, Zarcone R

机构信息

Department of Gynecology and Obstetrics, School of Medicine, II University of Naples, Italy.

出版信息

Panminerva Med. 1998 Jun;40(2):126-7.

PMID:9689833

Abstract

OBJECTIVE

To evaluate the impact of endometriosis on bone metabolism.

MATERIALS AND METHODS

We compared bone mineral density and biochemical markers (plasma osteocalcin, bone alkaline phosphatase, fasting urinary hydroxyproline, urinary excretion of cross-linked N-telopeptide of type I collagen) of bone turnover in forty-nine perimenopausal women undergoing laparotomy because of benign gynecologic pathology: in twenty-four of them (group A) endometriosis was diagnosed, the remaining twenty-five represented the control group (group B). Statistical analysis was performed by means of Student "t"-test; significance was set at p < 0.05.

RESULTS

Bone density of the lumbar spine (0.898 +/- 0.325 vs 0.940 +/- 0.350) and bone markers failed to show statistically significant differences between the two groups. No significant correlation was observed between any bone density measurement and severity of endometriosis.

CONCLUSION

Endometriosis does not seem to induce even in advanced stages, a reduction of bone density.

摘要

目的

评估子宫内膜异位症对骨代谢的影响。

材料与方法

我们比较了49名因良性妇科疾病接受剖腹手术的围绝经期妇女的骨密度和骨转换的生化指标（血浆骨钙素、骨碱性磷酸酶、空腹尿羟脯氨酸、I型胶原交联N端肽尿排泄量）：其中24例（A组）诊断为子宫内膜异位症，其余25例为对照组（B组）。采用Student "t"检验进行统计分析；显著性水平设定为p < 0.05。