Hasle H, Olsen J H, Hansen J, Friedrich U, Tommerup N
Department of Pediatrics, Aarhus University Hospital, Denmark.
Cancer Genet Cytogenet. 1998 Aug;105(1):39-42. doi: 10.1016/s0165-4608(98)00007-7.
Cytogenetic abnormalities in human malignancies frequently involve chromosome 7. The existence of several tumor suppressor genes on the long arm of chromosome 7 has been suggested in both epithelial and hematologic malignancies. From the Danish Cytogenetic Register, we identified 183 persons with constitutional abnormalities involving chromosome 7, including 16 patients with Williams syndrome. By linkage to the Danish Cancer Registry, we found five persons with cancer, including one thyroid carcinoma, three carcinomas of the digestive tract, and one malignant melanoma. There were no cases of leukemia. The overall risk of developing cancer was not increased.
人类恶性肿瘤中的细胞遗传学异常常常涉及7号染色体。在上皮性和血液系统恶性肿瘤中均提示7号染色体长臂上存在多个肿瘤抑制基因。我们从丹麦细胞遗传学登记处识别出183例患有涉及7号染色体的先天性异常的人，其中包括16例威廉姆斯综合征患者。通过与丹麦癌症登记处建立联系，我们发现5例患有癌症的人，包括1例甲状腺癌、3例消化道癌和1例恶性黑色素瘤。没有白血病病例。患癌的总体风险并未增加。
