Kohda Y, Chiao H, Star R A
Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, USA.
Curr Opin Nephrol Hypertens. 1998 Jul;7(4):413-7. doi: 10.1097/00041552-199807000-00011.
alpha-Melanocyte-stimulating hormone (MSH) is an endogenous anti-inflammatory cytokine that inhibits all major forms of inflammation, alpha-MSH level is increased at sites of inflammation in humans, and is produced in the pituitary and in macrophages. The effects of alpha-MSH are mediated by melanocortin receptors found on macrophages, neutrophils, and renal tubules. alpha-MSH inhibited ischemic acute renal failure in mice and rats, even when started 6 h after injury. alpha-MSH acts, in part, by inhibiting the maladaptive activation of genes that cause inflammatory and cytotoxic renal injury. However, alpha-MSH is effective even in the absence of neutrophils, suggesting that alpha-MSH also acts directly on renal tubules.
α-黑素细胞刺激素（MSH）是一种内源性抗炎细胞因子，可抑制所有主要形式的炎症。在人类炎症部位，α-MSH水平会升高，它由垂体和巨噬细胞产生。α-MSH的作用是通过巨噬细胞、中性粒细胞和肾小管上发现的黑素皮质素受体介导的。α-MSH可抑制小鼠和大鼠的缺血性急性肾衰竭，即使在损伤后6小时开始使用也有效。α-MSH部分通过抑制导致炎症性和细胞毒性肾损伤的基因的适应性不良激活来发挥作用。然而，即使在没有中性粒细胞的情况下，α-MSH也有效，这表明α-MSH也直接作用于肾小管。
