Zheliazkova-Savova M
Chair of Pharmacology, Varna Medical Medical University, Bulgaria.
Eksp Klin Farmakol. 1998 May-Jun;61(3):19-21.
The effect of isotheolin, a glaucin derivative, on the behavior of mice was studied under conditions of a model of preference of the dark section of the chamber to the light one which is used for appraisal of the anxiolytic/anxiogenic activity of substances. Intraperitoneal injection of isotheolin in a dose range of 0.25-4 mg/kg antagonized the anxiogenic effect induced by the serotonin agonist [correction of antagonist] chlorophenylpiperazine, mCPP (4 mg/kg). In a dose of 4 mg/kg isotheolin has an anxiolytic effect on intact animals. Bearing in mind that mCPP produces its anxiogenic effect via the 5-HT2C receptors, it is suggested that the mechanism of the anxiolytic action of isotheolin is realized through its interaction with the serotoninergic system at the level of 5-HT2C receptors.
在用于评估物质抗焦虑/致焦虑活性的明暗箱模型条件下，研究了格劳辛衍生物异泽兰黄素对小鼠行为的影响。腹腔注射剂量范围为0.25 - 4mg/kg的异泽兰黄素可拮抗血清素激动剂[拮抗剂更正为激动剂]氯苯哌嗪（mCPP，4mg/kg）诱导的致焦虑作用。4mg/kg剂量的异泽兰黄素对正常动物具有抗焦虑作用。鉴于mCPP通过5-HT2C受体产生其致焦虑作用，提示异泽兰黄素抗焦虑作用的机制是通过其在5-HT2C受体水平与血清素能系统相互作用来实现的。
