氧化应激与淀粉样变性

Oxidative stress and amyloidosis.

作者信息

Ando Y, Suhr O, el-Salhy M

机构信息

Department of Internal Medicine, Umeå University Hospital, Sweden.

出版信息

Histol Histopathol. 1998 Jul;13(3):845-50. doi: 10.14670/HH-13.845.

DOI:10.14670/HH-13.845

PMID:9690141

Abstract

From recent findings concerning free radical injury in several types of amyloidosis, it appears that free radical injury is involved either amyloid formation or in post-fibrillar modification. As we show in this review, among the more than 20 different types of amyloidosis, only a few types of amyloidosis present direct evidence of free radical involvement in amyloid formation. However, if we search further for other types of amyloidosis, other important information on free radical injury may be forthcoming. Free radical injury is probably central for the toxic properties of amyloid deposits.

摘要

从最近关于几种淀粉样变性中自由基损伤的研究结果来看，自由基损伤似乎与淀粉样蛋白的形成或纤维后修饰有关。正如我们在本综述中所表明的，在20多种不同类型的淀粉样变性中，只有少数几种淀粉样变性有自由基参与淀粉样蛋白形成的直接证据。然而，如果我们进一步研究其他类型的淀粉样变性，可能会获得关于自由基损伤的其他重要信息。自由基损伤可能是淀粉样沉积物毒性的核心。