Romiti A, Buzzetti R, Salandri A, Festuccia F, Giovannini C A, Santella S, Montesani C, Giovannini C
Istituto di II Clinica Medica, Università degli Studi di Roma La Sapienza.
Minerva Endocrinol. 1998 Mar;23(1):27-9.
The presence of nodules in the thyroid gland is the most frequent cause of endocrinopathy. The prevalence of thyroid nodules in the United States is estimated to be between 3-10%, whereas the prevalence of thyroid nodules in European adult population is estimated to be between 4-10%. At our Clinic of Obesity, the presence of nodules in the thyroid gland of obese patients is often found, incidentally, for this reason, we decide to investigate the prevalence of this pathology in obese patients and to quatify the number of times in which the presence of nodules had not been previously diagnosed.
3248 obese patients were examined during in the last six years (1991-1996); of these patients 747 were affected by obesity and thyropathy; of these 747 we took into consideration only those with a cold single nodule and correlated the presence of the nodule with BMI, sex and age.
The prevalence of a cold single nodule in the obese patients was 31%, of which 83% has not been previously diagnosed. Of cold nodules 8% was represented by carcinoma. The carcinoma appeared more often in females than in males (3:1). The incidence of cold nodules was more frequent in adults and in mild-medium obesity.
甲状腺结节的存在是内分泌疾病最常见的病因。据估计，美国甲状腺结节的患病率在3%至10%之间，而欧洲成年人群中甲状腺结节的患病率估计在4%至10%之间。在我们的肥胖诊所，经常偶然发现肥胖患者甲状腺中有结节，因此，我们决定调查肥胖患者中这种疾病的患病率，并量化此前未被诊断出结节的次数。
在过去六年（1991 - 1996年）期间对3248名肥胖患者进行了检查；其中747名患者患有肥胖症和甲状腺疾病；在这747名患者中，我们仅考虑那些有单个冷结节的患者，并将结节的存在与体重指数、性别和年龄相关联。
肥胖患者中单个冷结节的患病率为31%，其中83%此前未被诊断出。冷结节中有8%为癌。癌在女性中出现的频率高于男性（3:1）。冷结节的发病率在成年人和轻度至中度肥胖者中更为常见。
