Abe Y, Hayashi A, Yasufuku K, Oiwa T, Kurosu K, Mikata A
Department of Internal Medicine, Matsudo Municipal Hospital, Chiba, Japan.
Nihon Kokyuki Gakkai Zasshi. 1998 Apr;36(4):403-7.
A 60-year-old woman had an abnormal shadow in the right lower lung field on chest roentgenogram. Transbronchial lung biopsy revealed findings consistent with malignant lymphoma, and a right middle lobectomy was performed. Pathological findings showed that tumor cells had infiltrated the epithelium, forming so-called lymphoepithelial lesions. Flow cytometric analysis of the resected specimen revealed that B-cell associated antigens (CD 19, 20) were expressed, and that the tumor cells were CD 5-, CD 10-. A marked increase in the number of lymphocytes with an IgM kappa component suggested monoclonal origin for the tumor cells in the resected specimen. Southern blot analysis showed clonal rearrangement of the heavy chain of the immunoglobulin gene. A diagnosis of malignant lymphoma of bronchus-associated lymphoid tissue was made. This tumor was defined according to the revised European. American classification of lymphoid neoplasms as a marginal zone B-cell lymphoma.
一名60岁女性胸部X线片显示右下肺野有异常阴影。经支气管肺活检结果符合恶性淋巴瘤，遂行右肺中叶切除术。病理结果显示肿瘤细胞浸润上皮，形成所谓的淋巴上皮病变。对切除标本进行流式细胞术分析，结果显示B细胞相关抗原（CD 19、20）表达，肿瘤细胞CD 5阴性、CD 10阴性。具有IgM κ成分的淋巴细胞数量显著增加，提示切除标本中的肿瘤细胞起源于单克隆。Southern印迹分析显示免疫球蛋白基因重链的克隆性重排。诊断为支气管相关淋巴组织恶性淋巴瘤。根据修订后的欧美淋巴肿瘤分类，该肿瘤被定义为边缘区B细胞淋巴瘤。
