Ring H Z, Vameghi-Meyers V, Wang W, Crabtree G R, Francke U
Department of Genetics, Stanford University School of Medicine, Stanford, California, 94305, USA.
Genomics. 1998 Jul 1;51(1):140-3. doi: 10.1006/geno.1998.5343.
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors, are components of human SWI/SNF-like chromatin-remodeling protein complexes. We mapped five human SMARC genes toregions on four different human chromosomes, SMARCC1 to 3p23-p21, SMARCC2 to 12q13-q14, SMARCD1 to 12q13-q14, SMARCD2 to 17q23-q24, and SMARCD3 to 7q35-q36. SMARCC1, SMARCC2, and SMARCD1 are assigned to chromosomal regions that are frequently involved in somatic rearrangements in human cancers. SMARCD1 was mapped to the critical region of Allgrove syndrome; however, no mutation was identified in one Allgrove syndrome family studied.
与SWI/SNF相关的、与基质相关的、肌动蛋白依赖性染色质调节因子（SMARC），也称为BRG1相关因子，是人类SWI/SNF样染色质重塑蛋白复合物的组成部分。我们将五个人类SMARC基因定位到四条不同人类染色体上的区域，SMARCC1定位于3p23 - p21，SMARCC2定位于12q13 - q14，SMARCD1定位于12q13 - q14，SMARCD2定位于17q23 - q24，SMARCD3定位于7q35 - q36。SMARCC1、SMARCC2和SMARCD1被定位到人类癌症中经常发生体细胞重排的染色体区域。SMARCD1被定位到奥尔格罗夫综合征的关键区域；然而，在所研究的一个奥尔格罗夫综合征家族中未发现突变。
