Abisatov Kh A, Khan S V
Vopr Onkol. 1976;22(6):79-84.
The remote results in 295 patients subjected to radical surgical therapy are analysed, in 95 of these patients during two postoperative years 426 courses of chemotherapy were conducted. In squamous cell cancer of the lung 48 patients were administered methotrexate (90 mg per course), 18 patients with adenocarcinoma--5-fluoruracil, 29 patients with undifferentiated cancer-cyclophosphane (3 g of each substance). The comparison of 3 and 5-year results depending on the stage, extent of surgical intervention and histological form of the tumor, indicated a considerable prolongation of life terms in patients, subjected to the combined treatment, as compared with solely surgical one.
分析了295例接受根治性手术治疗患者的远期结果，其中95例患者在术后两年内进行了426个疗程的化疗。在肺癌鳞状细胞癌患者中，48例给予甲氨蝶呤（每疗程90毫克），18例腺癌患者给予5-氟尿嘧啶，29例未分化癌患者给予环磷酰胺（每种药物3克）。根据肿瘤分期、手术干预范围和组织学类型对3年和5年结果进行比较，结果表明，与单纯手术治疗相比，接受联合治疗的患者生存期显著延长。
