Simonenko V B, Aref'ev E Iu
Klin Med (Mosk). 1998;76(6):45-7.
68 elderly patients with hypertension stage II were treated with different combinations of antihypertensive drugs. 36 patients of group 1 received inhibitors of angiotension-converting enzyme (captopril) and calcium antagonists of prolonged action (adalat CL). 32 patients of group 2 received captopril and beta-blockers (atenolol). The patients were followed up for 12 months. Before and after the treatment the patients underwent 24-h monitoring of arterial pressure and echocardiography. The antihypertensive effect was more pronounced in group 1. Both combinations of the antihypertensive drugs prevented development and progression of myocardial hypertrophy due to hypertension. No significant changes in left ventricular contractility in response to these drug combinations were found.
68例老年II期高血压患者接受了不同组合的降压药物治疗。第1组36例患者接受血管紧张素转换酶抑制剂（卡托普利）和长效钙拮抗剂（拜心通控释片）治疗。第2组32例患者接受卡托普利和β受体阻滞剂（阿替洛尔）治疗。对患者进行了12个月的随访。治疗前后对患者进行了24小时动脉压监测和超声心动图检查。第1组的降压效果更为显著。两种降压药物组合均能预防高血压所致心肌肥厚的发生和进展。未发现这些药物组合对左心室收缩力有显著影响。
