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氨苯砜诱发的无皮肤过敏表现的肺嗜酸性粒细胞增多症——一次不寻常的经历——病例报告

Dapsone induced pulmonary eosinophilia without cutaneous allergic manifestations--an unusual encounter--a case report.

作者信息

Arunthathi S, Raju S

机构信息

Department of Medicine, Schieffelin Leprosy Research and Training Center, Karigiri, Tamil Nadu, India.

出版信息

Acta Leprol. 1998;11(1):3-5.

PMID:9693685
Abstract

Dapsone is a drug of choice in the treatment of leprosy. In addition it is very useful in the treatment of many other dermatological conditions. The "dapsone-induced hypersensitivity" is not unknown. However, to the best of our knowledge, pulmonary eosinophilia induced by dapsone without any cutaneous allergic manifestation has not been reported in leprosy patients. Pulmonary eosinophilia (Loeffler's syndrome) induced by dapsone without cutaneous manifestation has been reported in a non leprosy patient by Janier et al. We report a case of pulmonary eosinophilia associated with dapsone therapy in a patient with lepromatous leprosy without allergic cutaneous manifestations and our experience in the management of this patient.

摘要

氨苯砜是治疗麻风病的首选药物。此外,它在治疗许多其他皮肤病方面也非常有用。“氨苯砜引起的超敏反应”并非不为人知。然而,据我们所知,在麻风病患者中,尚未有氨苯砜诱发无任何皮肤过敏表现的肺部嗜酸性粒细胞增多症的报道。Janier等人曾报道过一名非麻风病患者出现了无皮肤表现的氨苯砜诱发的肺部嗜酸性粒细胞增多症(吕弗勒综合征)。我们报告了一例瘤型麻风病患者在接受氨苯砜治疗时出现无过敏性皮肤表现的肺部嗜酸性粒细胞增多症的病例以及我们对该患者的治疗经验。

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