Kelly C B, Cooper S J
Department of Mental Health, Queen's University of Belfast, UK.
J Psychopharmacol. 1998;12(2):161-7. doi: 10.1177/026988119801200208.
Plasma noradrenaline (NA) levels were compared between two groups of patients with major depressive disorder (melancholic/psychotic and non-melancholic), patients with general anxiety disorders and healthy controls. The melancholic/psychotic depressed group had the highest plasma NA levels. This only reached statistical significance with respect to the control group. Within the depressed group, there was no association between plasma NA levels and age, weight loss, ratings of depression, anxiety or plasma cortisol levels. Variance of plasma NA was greatest in the melancholic/psychotic depressed group. A review of previous studies shows an association between raised plasma NA, depressive illness and alterations in NA variance. This association may be limited to melancholic/psychotic depressed patients. The above findings support a dysregulated noradrenergic system in depressive illness.
比较了两组重度抑郁症患者（忧郁症/精神病性抑郁症患者和非忧郁症患者）、广泛性焦虑症患者与健康对照组之间的血浆去甲肾上腺素（NA）水平。忧郁症/精神病性抑郁症组的血浆NA水平最高。这仅与对照组相比达到统计学显著性。在抑郁症组内，血浆NA水平与年龄、体重减轻、抑郁评分、焦虑评分或血浆皮质醇水平之间没有关联。忧郁症/精神病性抑郁症组的血浆NA方差最大。对先前研究的综述表明，血浆NA升高、抑郁症与NA方差改变之间存在关联。这种关联可能仅限于忧郁症/精神病性抑郁症患者。上述发现支持抑郁症中去甲肾上腺素能系统失调。
